No - this is something completely different, unfortunately. Allergen response is mediated by T-helper type 2 (T_H2) cells, while autoimmune disorders like diabetes occur through a T-helper type 1 (T_H1) pathway.

With allergens, the foreign body will bind to antigen receptors on professional antigen presenting cells (usually dendritic cells), which will then present the bound antigen to T_H2 cells. These will then release a particular type of chemical called cytokines that will signal the B cells to produce a shit load of IgE antibodies tailored for the particular molecular pattern identified. The IgE will bind to the antigen and also to basophils and mast cells, which will secrete a bunch of chemicals, including histamines. This is what causes you to get all itchy. It’s also what causes swelling (such as when someone with a peanut allergy feels their throat closing up when they find out their snack had peanuts in it).

With Type 1 Diabetes, T_H1 cells will recognize patterns on the surface of your islet cells, and will then release a different set of cytokines that will attract cytotoxic T cells (T_C) to the area. These will bind to the surface of the islet cells, and will release a cocktail of chemicals that will kill the cell.

The mechanism by which allergen immunotherapy works is that it slowly trains your immune system to shift from a T_H2-dominated response to a T_H1-dominated response for that particular molecular pattern. This means that your body will treat the foreign substance as more of an invading pathogen (like a bacteria, for example) than an allergen, so there will not be the huge release of IgE antibodies, and consequently, far fewer mast cells and basophils releasing histamines. The precise mechanism of how this works is too complicated for this discussion, but suffice it to say we’re dealing with a completely different biological pathway than with self / non-self recognition, like what’s going on with autoimmune disorders.

Well… it’s not a cure. Not really. People with type I diabetes have a disorder where their immune system attacks their islet cells in their pancreas. These cells are what produce insulin. This therapy replaces some of the cells that they’ve lost, but it doesn’t stop their bodies from attacking those cells again. The way they’re doing that is by having the patients take immune-suppressing drugs forever, basically.

The problem with this is that there’s currently no way to target immune-suppressing drugs to say: “Hey, just stop attacking your own cells, but continue doing everything else an immune system is supposed to do.” By suppressing the immune system with these drugs, the patients are at an elevated risk of disease and cancer. And that’s forever. Or, at least until we figure out a better way to do it.

Still, it is a really cool therapy, in that they were able to direct the maturation of stem cells into insulin-producing islet cells, and they were able to successfully home those to the correct location. It’s huge progress, even if it isn’t actually a cure.

Same planes, but I’m guessing that they could confirm by satellite that at least 12 of them are wrecked beyond repair.

It’s like saying that H. H. Holmes has without doubt broken some laws.

God I’m so looking forward to seeing a +41 in the Aircraft section in tomorrow’s report. It’s gonna be like Christmas in June.

Einstein did once say: “I don’t know what weapons WWIII will be fought with, but WWIV will be fought with sticks and stones.”

I don’t think he foresaw a Russian using an RPG tube as a stick to whack a drone, though.

I’m guessing it’s the FPV drone. They’re strapped with explosives.

God damn, I hate these fucking nazis.

Fuck NBC for labeling their protest as “pro Gaza” instead of the much more accurate “anti-genocide”. I realize that our media is almost entirely owned by like 12 billionaires, but it still chafes.

The removal and the police brutality are two separate conversations.

Yeah, that was more my point with my initial post. I understand escorting someone from the premises if they are causing a huge scene, but these cops violently wrestled these people out of there, even employing a potentially lethal weapon on two occasions. Many people have died over the years from being tased, and so to see it being used so wantonly is incredibly disturbing.

Just because the property is public doesn’t mean the public can do whatever they want in it

Yes, but what those people were doing was exercising their first amendment rights. It’s not like they were going around punching people, or shouting “Fire!”. And considering that they were there attending a town hall, it’s really hard to make the case that they were loitering.

People who are interrupting whatever is going on can definitely be removed from the proceedings.

I don’t know that that’s true, legally speaking. I am, however, ignorant of a great many things, and this is definitely one area in which I feel a profound deficiency. But just because people routinely get abused in this way by the police doesn’t necessarily imply that it is legal for them to do so. As you point out in your next sentence, cops use violence with impunity, and our justice system tends to look the other way when they do.

I’m not well versed in property law, but the article says that the rally was at a community center. Does that necessarily imply that this is public, rather than private property? And if so, what possible justification could there be for the police to violently subdue people for exercising their freedom of speech on public property? Legal justification, that is. The MAGAts would obviously cite their hatred for all things pertaining to American freedoms (save those directly to do with bearing arms) as justification.

I’m not sure who, but someone from Russia seriously fucked up. That’s a huge get.

Oh shit - 4 helicopters? Nice!

I don’t… I really don’t understand what’s happening here. Are you pretending to be stupid to troll me or something? Is this how you get your jollies? By pretending to have a room temperature IQ to strangers online? Is it some weird kind of kink or something? Bro… are you using me to get your rocks off? Not fucking cool, man. You don’t just drag strangers into your kink. I did not consent to that shit. Go do your whole humiliation fetish thing somewhere else.

Alright, bud. I’d be very interested in seeing what math you do to make the $7 bn net income from FY 2024 (which I mentioned) into something other than $7 bn. Or the $122 bn total assets & equity (which I also mentioned) into something other than $122 bn. Like… what the fuck are you even talking about?

Source I’m using:

https://www.nasdaq.com/market-activity/stocks/tsla/financials

Hahah yep there we go… You haven’t been using publicly available data cause as far as I can see you haven’t referenced any number from their financials once

Err… what? I’ve referenced several numbers from their financials. What the fuck are you talking about?

If you want to know what their assets are worth without any fluff go right to their balance sheet

Uh yeah - I quoted that. Seriously, didn’t you say that you read everything I wrote? You couldn’t be bothered to skim it before posting this just to make sure you didn’t look like a dipshit when you hit reply?

Is this some sort of ploy to salve your ego in advance or something? I mean, Jesus. That’s truly pathetic.

Alright, well, I showed you mine. Let’s hear your valuation & rationale. My numbers are all based on the publicly available data. Let’s see what you got.

Also your valuation is still wrong hahaha. You thinking Tesla should be $12 and being able to prove that out with a fact pattern are two different things.

Well, you are at least correct about one thing. I was incorrect about the $12 stock price. In my defense, I wasn’t looking at the numbers at the time, just spitballing it. But going with the $45.5 bn valuation I mentioned previously, and their 3.5 bn outstanding shares, that would put the price per share at $13. I humbly accept the humiliation that comes with getting a hypothetical stock price incorrect by 8%.

I’m assuming here but I’m guessing you’ve need read a financial report, never done a dcf, have no idea how to model an investment and don’t know what PE ratios actually means.

I mean, I did allude to the fact that I think you might be an idiot before, and since you said that you read everything I wrote, I’ll just leave it at that. You’re not helping your case by being so hilariously wrong here.

Hey do me a favor let me know where I said Tesla was properly valued?

Are you slow, or something? This entire thread started because you were whining about people being hurt by Tesla losing money. Then, when I pointed out that it’s a bloated piece of shit and cited a valuation that was in the right ballpark, you said: “I don’t think you understand how valuations work”.

So, were you lying then, or are you lying now as you’re pretending that you agreed with me the entire time that Tesla is overvalued?