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Cake day: March 10th, 2025

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  • I’m a big fan and longtime reader of Derek Lowe. He called attention to suppression of grant funding for hypotheses that challenged the amyloid hypothesis, and the shockingly partisan and dogmatic behavior of journal referees and NIH advisors in the field. I’ve been following his coverage ever since he started reporting disappointing readouts from clinical trials on the anti-amyloid mABs.

    His concern that this class of therapy is “pathological science” (think cold fusion, or EmDrive, or string theory - not outright quackery, but hypotheses that are endlessly tweaked to justify the latest failures) are valid.

    However, the newest mABs really do seem to have a small but statistically significant effect on slowing disease progression. Enough to justify the risks of brain swelling? Or the cost? Probably not. But I think Derek has perhaps swung too far in the opposite direction. It’s too early to call time on this therapeutic target. If it’s marginally but truly effective, we should try to figure out why, and keep tweaking the drugs to see if they can be improved.

    Donepezil was a dead end, but it’s too early to say if Aduhelm is too.







  • you’re right, apparently. from Wikipedia:

    The U.S. Army defines assault rifles as “short, compact, selective-fire weapons that fire a cartridge intermediate in power between submachine gun and rifle cartridges.”

    AR-15 is semi-auto rather than selective fire, so it’s not an assault rifle. I had mistakenly conflated assault rifles with “assault weapons,” which is a separate (and more vague and contested) term.

    you can still buy an M-16 or AK-47, but it has to be transferrable (grandfathered in before FOPA) and you need extra paperwork.



  • uuldika@lemmy.mltoProgrammer Humor@programming.devWhy indeed
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    15 days ago

    Java (and Object Pascal, I’m assuming) have very old-looking UIs. Discord’s gonna have trouble attracting users if their client looks like a billing system from 2005. Also, what do you do about the web client? Implement the UI once in HTML/CSS/JS, and again in JForms?

    So if you’re picking one UI to make cross-platform, and you need a web client, do you pick JForms and make it work on the web? or React and make it work on desktop?